IGF1R -> MEK1 ERBB1 -> MEK1 ERBB2_3 -> MEK1 ERBB1_2 -> MEK1 ERBB1_3 -> MEK1 p21 -| CDK4 CyclinD1 -> CDK4 p27 -| CDK4 CDK4 -| p21 AKT1 -| p21 MYC -| p21 MEK1 -> CyclinD1 ERalpha -> CyclinD1 AKT1 -> CyclinD1 MYC -> CyclinD1 CDK4 -| p27 CDK2 -| p27 AKT1 -| p27 MYC -| p27 p21 -| CDK2 p27 -| CDK2 CyclinE1 -> CDK2 MYC -> CyclinE1 CDK4 -> pRB1 CDK6 -> pRB1 MEK1 -> ERalpha AKT1 -> ERalpha IGF1R -> AKT1 ERBB1 -> AKT1 ERBB2_3 -> AKT1 ERBB1_2 -> AKT1 ERBB1_3 -> AKT1 CyclinD1 -> CDK6 MEK1 -> MYC ERalpha -> MYC AKT1 -> MYC ERalpha -> IGF1R AKT1 -> IGF1R ERBB2_3 -| IGF1R EGF -> ERBB1 EGF -> ERBB2 EGF -> ERBB3 ERBB2 -> ERBB2_3 ERBB3 -> ERBB2_3 ERBB1 -> ERBB1_2 ERBB2 -> ERBB1_2 ERBB1 -> ERBB1_3 ERBB3 -> ERBB1_3 $AKT1: ((((((((!IGF1R & !ERBB1) & !ERBB2_3) & !ERBB1_2) & ERBB1_3) | (((!IGF1R & !ERBB1) & !ERBB2_3) & ERBB1_2)) | ((!IGF1R & !ERBB1) & ERBB2_3)) | (!IGF1R & ERBB1)) | IGF1R) $CDK2: ((!p21 & !p27) & CyclinE1) $CDK4: ((!p21 & CyclinD1) & !p27) $CDK6: CyclinD1 $CyclinD1: ((((!MEK1 & ERalpha) & AKT1) & MYC) | ((MEK1 & ERalpha) & MYC)) $CyclinE1: MYC $EGF: true $ERBB1: EGF $ERBB1_2: (ERBB1 & ERBB2) $ERBB1_3: (ERBB1 & ERBB3) $ERBB2: EGF $ERBB2_3: (ERBB2 & ERBB3) $ERBB3: EGF $ERalpha: ((!MEK1 & AKT1) | MEK1) $IGF1R: (((!ERalpha & AKT1) & !ERBB2_3) | (ERalpha & !ERBB2_3)) $MEK1: ((((((((!IGF1R & !ERBB1) & !ERBB2_3) & !ERBB1_2) & ERBB1_3) | (((!IGF1R & !ERBB1) & !ERBB2_3) & ERBB1_2)) | ((!IGF1R & !ERBB1) & ERBB2_3)) | (!IGF1R & ERBB1)) | IGF1R) $MYC: ((((!MEK1 & !ERalpha) & AKT1) | (!MEK1 & ERalpha)) | MEK1) $p21: ((!CDK4 & !AKT1) & !MYC) $p27: (((!CDK4 & !CDK2) & !AKT1) & !MYC) $pRB1: (CDK4 & CDK6)